Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
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چکیده
منابع مشابه
Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
The innate immune protein Stimulator of interferon genes (STING) promotes the induction of interferon beta (IFN-β) production via the phosphorylation of its C-terminal tail (CTT) by TANK-binding kinase 1 (TBK1). Potent ligands of STING are, therefore, promising candidates for novel anti-cancer drugs or vaccine adjuvants. However, the intrinsically flexible CTT poses serious problems in in silic...
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PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2016
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2016.05.039